Mimicry to Enter Host Cells Vaccinia Virus Uses Macropinocytosis
نویسنده
چکیده
http://www.sciencemag.org/cgi/content/full/320/5875/531 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/320/5875/531/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http://www.sciencemag.org/cgi/content/full/320/5875/531#related-content http://www.sciencemag.org/cgi/content/full/320/5875/531#otherarticles , 14 of which can be accessed for free: cites 25 articles This article 6 article(s) on the ISI Web of Science. cited by This article has been http://www.sciencemag.org/cgi/content/full/320/5875/531#otherarticles 3 articles hosted by HighWire Press; see: cited by This article has been http://www.sciencemag.org/cgi/collection/virology Virology : subject collections This article appears in the following
منابع مشابه
Vaccinia virus strains use distinct forms of macropinocytosis for host-cell entry.
To enter host cells, vaccinia virus, a prototype poxvirus, can induce transient macropinocytosis followed by endocytic internalization and penetration through the limiting membrane of pinosomes by membrane fusion. Although mature virions (MVs) of the Western reserve (WR) strain do this in HeLa cells by activating transient plasma membrane blebbing, MVs from the International Health Department-J...
متن کاملVaccinia extracellular virions enter cells by macropinocytosis and acid-activated membrane rupture
Vaccinia virus (VACV), the model poxvirus, produces two types of infectious particles: mature virions (MVs) and extracellular virions (EVs). EV particles possess two membranes and therefore require an unusual cellular entry mechanism. By a combination of fluorescence and electron microscopy as well as flow cytometry, we investigated the cellular processes that EVs required to infect HeLa cells....
متن کاملA Differential Role for Macropinocytosis in Mediating Entry of the Two Forms of Vaccinia Virus into Dendritic Cells
Vaccinia virus (VACV) is being developed as a recombinant viral vaccine vector for several key pathogens. Dendritic cells (DCs) are specialised antigen presenting cells that are crucial for the initiation of primary immune responses; however, the mechanisms of uptake of VACV by these cells are unclear. Therefore we examined the binding and entry of both the intracellular mature virus (MV) and e...
متن کاملThe Ebola virus glycoprotein mediates entry via a non-classical dynamin-dependent macropinocytic pathway.
Ebola virus (EBOV) has been reported to enter cultured cell lines via a dynamin-2-independent macropinocytic pathway or clathrin-mediated endocytosis. The route(s) of productive EBOV internalization into physiologically relevant cell types remain unexplored, and viral-host requirements for this process are incompletely understood. Here, we use electron microscopy and complementary chemical and ...
متن کاملAppraising the apoptotic mimicry model and the role of phospholipids for poxvirus entry.
Entry of vaccinia virus (VACV) into cells occurs by fusion with the plasma membrane and via a low pH-dependent endosomal pathway, presumably involving unidentified cellular receptors. In addition to approximately 25 viral proteins, the membrane of VACV mature virions contains several phospholipids including phosphatidylserine (PS). A recent model posits that PS flags virions as apoptotic debris...
متن کامل